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Validated writers and erasers can be quantified using in-vitro reconstitution with site-resolved proteomics and extended to chromatin-relevant contexts [43, 44, 59, 71, 78], and patient-oriented readouts can combine quantitative LCMS with standardized tissue assays and, where feasible, noninvasive measures of lactate flux [52, 88, 384, 391, 392]

this rules out the non-specific effects of confounders in HFD-fed mice

These included enhanced reepithelialization, wound contraction, collagen deposition, and angiogenesis

Improved Motility and Function: Supports smoother intestinal contractions and regular digestive processes in injured areas