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10.3389/fphys.2016.00423 10 CcW

Choline, inositol, and methionine are discussed in relation to methyl-donor balance, membrane biology, and nutrient metabolism

Amino acid metabolism and disease

Subsequently, Yagoda and Yangs groups demonstrated that iron chelators could inhibit this type of cell death, discovered that Ras-selective lethal 3 (RSL3) mimicked Erastins effects in RAS-mutant cells, and found that elevated levels of ROS and iron were closely associated with RAS signaling (Yagoda et al., 2007