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The thoracic aortas were surgically excised and carefully cleared of surrounding tissues

Ferric iron (Fe 3+ ) is stored within ferritin in the cytoplasm, whereas Fe 2+ for ferroptosis induction is either imported via CD44 from the extracellular compartment [22] or provided via lysosomal ferritin degradation and subsequent reduction [23]

Supporting this mechanism, studies in animal models demonstrate that L-carnitine administration increases the expression of mitochondrial superoxide dismutase-2 (SOD2), reduces markers of inflammation, and alleviates overall oxidative burden (63)

Again, though, these actions are largely characterized in cell and animal systems, and their relevance to visible human skin change depends entirely on whether an effective concentration reaches the dermis by the route in question