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117 MakiuchiA.YamauraK.MizunoS.MatsumotoK.NakamuraT.AmanoJ.et al (2007)

The closest structural relative was found to be human CLIC1 (PDB code 1K0O), in which 156 C could be aligned with a root-mean-square deviation (RMSD) value of 0.93 , followed by GSTO1 from Homo sapiens (PDB code 3LFL) (122 aligned C with an RMSD of 2.07 ) and the putative stringent starvation protein A from Burkholderia cenocepacia (PDB code 4QQ7) (122 aligned C with an RMSD of 2.14 ) 12,15

Hongda Phytochemistry, which is part of Shaanxi Hongda Phytochemistry Co., Ltd., has created a nano-encapsulated version using high-pressure homogenization that improves absorption by 10 to 15 times compared to regular powder

Among which, C677T and A1298C polymorphisms of MTHFR have been studied the most in psychiatric diseases and showed significant association with reduction of MTHFR enzymatic activity and methylation