PKM2-mediated Warburg effect has been found to cause ferroptosis, and formaldehyde can induce ferroptosis by up-regulating the Warburg effect in hippocampal neuronal cells (210, 211)
As a result, using antioxidants to reduce ROS generation could be an effective strategy for lowering oxidative stress-related problems
In contrast, compounds 6 , 13 , 39 , 42 , 49 , 52 , 53 , 54 , 60 , 61 , 62 , 87 , and the drug allopurinol were predicted not to inhibit any of the five CYP450 isoforms
Granule-like neurons at the hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells: functional implications of seizure-induced neurogenesis