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Signaling pathways associated with oxidative stress in GDM An excess of ROS can enhance inflammatory responses through the activation of various kinases and transcription factors, including the nuclear factor-kappa B (NF-B) [18]

The area under the curve (AUC) in a ROC plot summarizes the sensitivity/specificity trade-off of a predictive model over all possible thresholds

More specifically, the reactive oxidative species (ROS) affect microenvironments associated with the fluid surrounding the egg, fallopian tube fluid, and abdominal fluid and have a direct bearing on egg quality (cell membranes, mitochondria & DNA), sperm-egg interaction (fertilization), sperm-mediated egg activation, implantation, and early embryo development

Additional studies are needed to further determine the limitations of the translational protein markers in other conditions such as liver disease during APAP-induced liver injury