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Med Sci Monit (2010) 16:Cr62832

Saturation and diminishing returns: Beyond certain dose, additional peptide provides minimal incremental benefit as receptors become saturated or downstream pathways maximally activated

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Additionally, certain variants in genes related to antioxidant response, such as the catalase (CAT) gene and the glutathione peroxidase (GPX) gene, have been associated with increased susceptibility to vitiligo.67,69,70 Furthermore, vitiligo has been associated with defective recycling of tetrahydrobiopterin (6BH4), essential for melanin formation, leading to an excess of 7BH4 and inhibition of phenylalanine hydroxylase (PAH)