Heres data from a meta review on the relative risk of various health conditions as a function of the number of US standard drinks (14g of alcohol) someone has in a day: The three small dots show that having 10 drinks a day is associated with a 9x risk of getting lip/oral cancer, a 3x risk of epilepsy, and a 1.5x risk of diabetes, as compared with not drinking at all
Tosic M, Ott J, Barral S, Bovet P, Deppen P, Gheorghita F et al (2006)
This allows for reactions with a broad spectrum of both physiological metabolites (such as estrogen, prostaglandins, and leukotrienes) and xenobiotics (including acetaminophen, persistent organic pollutants, and toxic metals such as mercury, arsenic, and lead)
Selenium is an essential element that makes up GPx and is important for GPx to exert appropriate antioxidant functions