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IN OUR INSTITUTION, we have had recent requests for information on manipulation of glutathione (GSH) concen-trations in patients, and have observed the recent and growing body of literature on this topic

In this review we briefly summarize the mechanisms of GSH synthesis and homeostasis, while we will focus on the strict connection between GSH levels and oxidative/nitrosative stress and on the downstream redox changes that modulate signaling pathways involved in viral infection and autophagy (ATG)

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