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Dans les annes 2000, beaucoup de fumeurs taient dj dpendants au tabac la fin de leur adolescence (16-20 ans), mme si l'initiation prcoce a diminu pour les deux sexes et dans toutes les rgions (sauf en Europe du Sud, o le dclin s'est stabilis aprs 1990)

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A statistically insignificant correlation was noted between serum cotinine concentrations and serum/urine quotients, as elevated cotinine concentrations correlated with lower serum/urine quotients among RS individuals