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3 The self-medication hypothesis: a was first described by Khantzian to explain cocaine use by people with mental illnesses b has already been discarded by clinicians and policy makers c proposes that smoking reduces mortality rates in people with schizophrenia d proposes that people with schizophrenia tend to substitute antipsychotics with nicotine e is weakened by the finding that nicotine improves attention levels in people with schizophrenia to the same degree as in healthy controls