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Gaseous co-transmitters like NO are conceptually attractive candidates for involvement in these dual processes, as their diffusible nature could allow signaling across both recently activated and recently passive circuits within a given region in tandem

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In a 2013 study by Korenevsky et al., the researchers administered a combination of melatonin and epithalon to female rats exposed to suboptimal environmental factors, such as light pollution, finding that the combined therapy rectified various impairments of the hypothalamic-pituitary-gonadal axis [13]