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In other words, the companies that have delighted in addicting the public to their legal drugs for decades are now busily buying up newfangled addiction sellers, keeping the business of addiction in largely the same hands

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Abbreviations ApoE: atherosclerosis-prone apolipoprotein E-deficient ALDH2: Aldehyde dehydrogenase 2 Bax: bcl-2-associated X protein Bcl-2: B-cell lymphoma 2 BMD: Bone mineral density BMI: Body mass index BSP: Bone sialoprotein CBD: cannabidiol COL1: Type 1 collagen E-cig: electronic cigarette GRP55: G protein-coupled receptor 55 MMP: Matrix metalloproteinase NF-B: nuclear factor kappa-light-chain-enhancer of activated B cells NHBE: normal human bronchial epithelial OPG: osteoprotegerin PGE2: Prostaglandin E2 RANK-L: Receptor activator of nuclear factor kappa beta ROS: reactive oxygen species RUNX2: Runt-related transcription factor 2 TIMP: Tissue inhibitors of metalloproteinase References Patel RA, Wilson RF, Patel PA, Palmer RM