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However, HE staining showed slight folding, shrinking and delamination of the basement membrane of seminiferous tubules in the rat testicular tissue, an increasing amount of sperm, insignificant damage to spermatogenesis, a lack of mature spermatogenic cells, a slightly disordered and sparse cell arrangement with 35 layers and visible cell polarity in groups C and D

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These results suggest that many of the beneficial effects of CR on memory, especially in males, may result from reduced tau pathology or altered molecular signaling, and not from the reduction in plaques

8 These findings underscore the relevance of TMAO as both a biomarker and therapeutic target in cardiometabolic diseases