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Result By formulation drug into nanoemulsion, it is helpful to avoid rapid nasal clearance and increase mean residence time in the nasal cavity, also enhancing permeation of the drug, which facilitates the entry of the drug directly into the brain, which is beneficial to reduce the degeneration of dopaminergic neurons by avoiding -synuclein formation

[DOI] [PMC free article] [PubMed] [Google Scholar] 123.Uebel-von Sandersleben H., Rothenberger A., Albrecht B., Rothenberger L.G., Klement S., Bock N

These products may not meet pharmaceutical quality standards and could pose safety risks

On the other hand, 22 metabolic pathways were significantly downregulated in GDH3 -deleted cells cultured in MM medium and only oxidative phosphorylation, sulphur metabolism, biotin metabolism, pyrimidine metabolism, and glycolysis/gluconeogenesis were upregulated