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This produces a steric hindrance that prevents AA from being metabolized

By significantly reducing the size and activity of sebaceous glands, Accutane decreases oil production, which is a primary contributor to acne formation

In line, Grx2 knockout mice resemble phenotypes of mice expressing a hypomorphic Gpx4 allele, such as lipid peroxidation in the brain or loss of parvalbumin-positive neurons [71]