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Despite significant success in hematologic malignancies, the efficacy of immunotherapies in solid tumors remains limited, largely due to the immunosuppressive nature of the microenvironment

For women, E 2( t ), varies from 0.135 to 1.156 nM over the course of the cycle [24,25] , and for men, E2 is a constant 0.09 nM [26]

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