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Discussion Identifying compounds that selectively bind to the active and regulatory sites of proteins is a well established method in defining the substrates and catalytic intermediates of enzymes, and ligands for receptors (Weller, 2012)

In animal models of ALS, dysfunction of mitochondria in motor neurons occurs before any other observable pathologic changes, suggesting this is an early event in the progression of the disease (Kong 1998)

Additionally, absorption issues due to gastrointestinal (GI) problems and food sensitivities may limit the availability of selenium from food sources

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