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We also observed that oxidative damage occurred in the D-gal induced aging mouse brain, and this damage was reversed by PQQ intervention

662 This latter type of astrocyte was also detected in argyrophilic grain disease, in AD and HD

These results, combined with the observed inhibition of the Toll-like receptor signaling pathway and the NF-B signaling pathway, indicate that the TLR2/4-NF-B signaling pathway plays a crucial role in mediating the alleviation of oxidative stress-induced inflammatory damage by astaxanthin

In the liver, the GSH/GSSG ratio was reduced by two-thirds and redox potential (EGSSG/2GSH) was less negative in KO mice 17