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Nitric oxide (NO) accumulation mediated by glutamate receptors (GLRs) is a hallmark of neuronal dysfunction and has been linked to the pathogenesis of several neurodegenerative diseases

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The accumulation of adenosine in the extracellular space produces a potent anti-inflammatory effect, including a reduction in the number of activated T cells, and a reduction of TNF- levels (Montesinos et al, 2003

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