Sun exposure is a primary cause of increased melanin production, leading to dark spots and uneven skin tone
PM localization of the G protein Go, showed that these two localizations are independent from the previously assumed Golgi-to-PM trafficking, and discovered a general mechanism controlling PMP localization to its target membrane through the substrate selectivity of differently localized PATs
These findings suggest that the HSB differs from terrestrial mammals and birds in the major sites of creatine synthesis
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