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The balance between diketone and keto-enol forms is strongly influenced by temperature, pH, and solvent polarity (77), and the enol-to-keto ratio is a significant determinant of curcumins pharmacological properties (78)

Author contributions YP: Project administration, Investigation, Funding acquisition, Writing original draft

doi: 10.22271/chemi.2020.v8.i2aj.9107 142

These medications include semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), exenatide (Byetta, Bydureon BCise), and tirzepatide (Mounjaro, Zepbound)though tirzepatide is technically a dual GIP/GLP-1 receptor agonist