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Collectively, our data reveal that Y37P substitution in Cagri (from Amy) promotes differential engagement of the Cagri peptide with each RAMP that contributes to distinct conformational dynamics from those observed for each individual rAmy-bound AMYR complex

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After first-line treatments and diagnostics, including diet change, addition of probiotics, and fecal analysis, were performed, a GI panel determined serum cobalamin, folate, and trypsin-like immunoreactivity