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Because Dihexa activates HGF/c-Met signaling , and this pathway is also involved in some types of tumor progression, caution is advised in: Patients with active cancers History of certain malignancies No human data confirms a cancer risk, but Dihexa is best avoided in patients with cancer unless under strict clinical supervision

Practical considerations must be taken into account when preparing and handling peptides in solution

Meningococcal infection induces sphingosine phosphorylation through SphK1 in a mechanism strictly dependent on pili-mediated interaction with the cell (Fohmann et al., 2023)

To further verify whether OGD treatment could cause endothelial cell senescence, -galactosidase (SA--gal) staining was performed on the endothelial cells treated with OGD