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Here are some common setbacks I encountered: Timing and Administration : I had to master the timing and technique of my injections

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cuprizone (CPZ) group, administered 0.6% CPZ for 4 weeks, sham group, administered 0.6% CPZ and dimethyl sulfoxide for the same period, and AST group, administered cuprizone CPZ daily along with administered AST at a dose of 3 mg/kg administered 12 h later for 4 weeks

However, IGF-1R is highly expressed in cerebral plexus (CP), hypothalamus, thalamus, amygdala, and hippocampus/parahippocampal gyrus