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Demiroglu Science University Florence Nightingale Journal of Medicine , 10 (3), 123128

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A study in Taiwan found that 48% of the control population had a copy of the (dominant) ALDH2*2 mutation that slows the breakdown of acetaldehyde, but only 12% of alcoholics did

FIGURE 2 In 1976 Benson and Talalay discovered that the cytosolic fraction of rat liver catalyzes the same steroid isomerization of 5-androsten-3,17-dione, but in distinction from the bacterial enzyme the reaction included reduced glutathione as a designated coenzyme ( 1 mg 1 ) in comparison with the five orders of magnitude higher activity of the Pseudomonas enzyme ( In retrospect, it is clear that the ketosteroid isomerase activity of the GST in human liver ( 1 B 1 and B 1 B 2 in Mechanism of Ketosteroid Isomerase Catalyzed by Mammalian Glutathione Transferases The double-bond isomerization of ketosteroids has been investigated with 5-AD and 5-PD (Figure 2)