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First, it is predominantly driven by metabolic alteration factors (glucotoxicity and lipotoxicity), although this does not exclude contributory inputs from low-level circulating PAMPsarising, for example, from increased intestinal permeabilityas well as DAMPs released during regulated or necrotic cell death, and, in selected settings, hypoxia or other forms of low-intensity tissue injury

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In: Arafa M, Elbardisi H, Majzoub A, Agarwal A (eds) Genetics of Male Infertility: A Case-Based Guide for Clinicians