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Simultaneously, the assembly and activation of the NLRP3 (nucleotide-binding domain-like receptor family pyrin domain containing-3) inflammasome complex, regulated by NF-kB, are enhanced in neurons, microglia, and astrocytes within the trigeminal ganglia, trigeminal nucleus caudalis, and cortical areas (9, 10, 39, 47)

115 These cytokines can be systemically upregulated, or produced by synoviocytes, chondrocytes, or meniscal cells