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FIGURE 6 5.1 In vitro tests Caudatin has been found to exhibit significant growth inhibition and induces apoptosis in a variety of cancer cell lines, such as hepatocellular carcinoma cell lines (HepG2 and SMMC-7721), breast carcinoma cell line (MCF-7) and lung carcinoma cell line (A549), with IC 50 values ranging from 3.11 to 44.68 mol/L ( 5.2 In vivo tests Studies conducted in animals such as rats and mice showed that caudatin did not cause significant side effects or systemic toxicity at therapeutic doses ( 6 Conclusion This review highlights the therapeutic viability of caudatin from structural optimization, pharmacological mechanism, and clinical implications, suggesting it as a multi-facilitive scaffold for drug discovery

The Limitations of Traditional Melasma Treatments Conventional approaches to treating melasma have included: Topical agents (hydroquinone, retinoids, corticosteroids) Chemical peels Conventional laser therapies Oral medications Lifestyle modifications Sun protection measures While these methods can offer some improvement, they often fall short of delivering comprehensive, long-lasting results

Cell Mol Life Sci 71(18):34893506 Van Dyken P, Lacoste B (2018) Impact of metabolic syndrome on neuroinflammation and the bloodbrain barrier