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Pharmacokinetics of oltipraz and its major metabolite (RM) in patients with liver fibrosis or cirrhosis: relationship with suppression of circulating TGF-beta1

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Benton CB, Al Rawi A, Wang F, Zhang J, Jorgensen JL, Mu H, Schober W, Alaniz Z, Gumbs C, Futreal A, Garcia-Manero G, Kantarjian HM, Navin N, Konopleva MY, Andreeff M

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Berberine also inhibits MMP-9 activity, thereby facilitating neuroinflammation and BBB disruption

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