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Conventionally, the main goal of radiotherapy has been to kill cancer cells, notwithstanding the local immunosuppression through various pathways such as vascular disruption and hypoxia, which might result in diminished recruitment of certain immune effector cells, exhaustion of effector T cells, and stimulation of regulatory T cells (321, 332334)

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for example, the TLR4/NF-B/IL-1 signaling pathway is activated in chronic SZ patients (197), and clozapine reduces the expression of pro-inflammatory genes such as IL-1 and IL-6 by inhibiting the TLR4/NF-B pathway (198)

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