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Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities

It plays a central role in: Neutralizing reactive oxygen species (free radicals) Supporting liver detoxification pathways Maintaining immune and mitochondrial health Protecting proteins and DNA from oxidative damage Low glutathione levels or an impaired glutathione system are associated with increased oxidative stress, which contributes to fatigue, inflammation, and slower recovery

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Research involving glutathione suggests strongly that it has an important role in preventing oxidative stress-associated lipid peroxidation which subsequently makes maintaining an optimal balance of glutathione necessary for it to effectively quench peroxidation of the lipid membranes