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Smoking immediately afterward adds further strain on the heart, increases blood clotting, and can raise the risk of cardiovascular eventsespecially in people with genetic predispositions, high blood pressure, or diabetes

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For example, the HPH model only reflects the pathological characteristics of hypoxia-induced PH, and cannot simulate the core disease characteristics of PAH such as the genetic background of IPAH (e.g., BMPR2 mutation) and the hemodynamic abnormalities of CHD-PAH, making it difficult to fully reveal the regulatory rules of UPS in PAH

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