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Spinal stenosis is common and can happen anywhere in the spine but usually occurs in the lumbar spine (low back) and the cervical spine (the neck) because these are the most mobile parts of the spine and therefore most prone to wear and tear

Daily dosing is the standard research convention

The IRB authorized the exemption of informed consent from the subjects

All study participants were randomly assigned to an experimental treatment group that received subcutaneous injection of cagrilintide, once-weekly, in doses of either 0.3, 0.6, 1.2, 2.4, or 4.5 mg, as well as a one-daily 3.0 mg dose of liraglutide, and a volume matched placebo for control purposes