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However, this question is controversial in humans [19-21]

Peroxynitrite is highly toxic to neurons and causes hyper-excitability of the central nervous system, a process known as "kindling." This leads to autonomic nervous system dysfunction (dysautonomia), sensory overload, and severe cognitive deficits

DNA binding triggers tetramerization of the glucocorticoid receptor in live cells

The limitations of this study include the limited efficacy of TIR in mitigating DXN-induced mortality, weight loss, and oxidative stress, as well as the absence of histological validation for the neurological observations, particularly within the cortex and hippocampus