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Random trial and error can cause more damage

Subsequently, at the distal part of the colon, tyrosine, phenylalanine, and tryptophan amino acids from endogenous, dietary, or microbial metabolism (Koppe et al., 2018) are utilized by bacteria for growth, metabolizing them to various end products, including indoles and phenols, which serve as precursors for the formation of cardio- and neuro-toxic uremic toxins (Krukowski et al., 2023)

Separate from that, every product that's in the operating room I've covered this every time I've been on here every single 90% of the products in the operating room never had a human safety study

Some insurers require step therapy (trying other medications first) or documentation of a formal alcohol use disorder (AUD) diagnosis and detox completion