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[DOI] [PMC free article] [PubMed] [Google Scholar] 231.Brohan J., Goudra B.G

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The nucleocytoplasmic reductive shift during fasting is likely beneficial, as the [NAD + ] levels increase to activate sirtuins and the [NADH] levels increase to an even greater extent to activate the malate-aspartate shuttle (MAS) to potentially reduce the mitochondrial matrix [NAD + ]/[NADH], which may also play a role in neuroprotection and delayed aging