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acidophilus produces SCFAs like acetate, which activate Intercellular adhesion molecule-3-Grabbing Non-integrin Receptor 3 (SIGNR3) receptor on dendritic cells, suppressing IL-6/STAT3 and RORt pathways to inhibit Th17 differentiation while promoting Treg expansion, helping restore immune balance ( L.plantarum and A.muciniphila secrete metabolites that bind TLR2, downregulating NF-B to block the IL-23/Th17 axis, Additionally, A