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Description

Animal model research demonstrated that depleting GSH via inhibition of GCL triggered a cascade of lipid peroxidation and cell death in mesencephalic cultures, identifying oxidative stress from glutathione insufficiency as a likely initiating mechanism in neurodegeneration

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Our data suggest that Retatrutides therapeutic potency results from a synergistic interplay between central and peripheral mechanisms

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JH: Conceptualization, Supervision, Writing review & editing

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PubMed, Nebert, Daniel W., and Vasilis Vasiliou

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