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In contrast to biomarkers of exposure (BoEs) that reflect exposure to certain substances, chemicals or products, BoPHs are biological indicators that reflect early changes in health status caused by exposure to harmful substances (e.g., tobacco smoking) and are used to evaluate the risk of developing disease before clinical symptoms appear

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Countries where no estimate can be calculated are included in regional and global averages by assuming their prevalence rates for men and women are equal to the average rates for men and women seen in the UN subregion1 in which they are located