The metabolic reprogramming of cancer cells, known as the Warburg effecttransitioning from predominantly oxidative metabolism to glycolysis and generating lactate even in oxygen-replete environments, supports the high demands for energy, biosynthesis, and acidic microenvironment needed to maintain the malignant cancer cell state, including proliferative and metastatic phenotypes [21, 23]
Plant Physiol 110:13671379 Mellersh DG, Foulds IV, Higgins VJ, Heath MC (2002) H 2 O 2 plays different roles in determining penetration failure in three diverse plant-fungal interactions
Mol Biol Rep 53 , 337 (2026)
In particular, it was found that ephrin-B2 is able to control VEGF signalling by inducing VEGFR2 and VEGFR3 internalization, thereby regulating angiogenesis and lymphangiogenesis in physiological conditions as well as during tumor progression [169, 170]