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Funding This research was funded by the National Natural Science Foundation of China (Grant Numbers 81870068, 81900066, 82070063), Natural Science Foundation of Guangdong province (Grant Number 2019A1515012110, 2021A1515012595), Key Laboratory of Emergency and Trauma (Hainan Medical University), Ministry of Education (Grant Number KLET-202102) and Youth Project of Dean's Fund of Nanfang Hospital, Southern Medical University (Grant Number 2019C006)

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