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This method also activates the mitochondrial system, initiating an apoptosis signaling amplification loop through cleavage of the BH3-interacting-domain death agonist (BID) protein, producing the active truncated BID fragment and ensuring irreversible cell death (73)

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The concentration of microplastics differs significantly across environments, ranging from 6.2 particles/100m in marine surface waters to 91 55 items/g dry weight in coastal sediments (Liu et al., 2022a)