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Products that deliver nicotine without combustion present a fundamentally different risk profile

Upon inhalation, they can induce inflammation and oxidative stress in the lung, which enter the systemic circulation delivering pro-inflammatory cytokines and chemokines, as well as free radicals which are able to cross the blood-brain barrier (BBB) to act on the brain (Chan et al., 2020

According to the American Lung Associations newly released 2025 State of Tobacco Control report, the tobacco industry is taking more aggressive actions at the federal and state levels to stop policies to prevent and reduce tobacco use

Chen R, et al