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Chronic low-grade inflammation accompanying these conditions is mediated by activation of several molecular pathways, notably NF-B, MMP-9 (matrix metalloproteinase-9), MAPKs (mitogen-activated protein kinases), COX-2 (cyclo-oxygenase-2), and STAT-3 (signal transducer and activator of transcription-3)

Sattar N, McConnachie A, Shaper AG, Blauw GJ, Buckley BM, de Craen AJ, Ford I, Forouhi NG, Freeman DJ, Jukema JW, Lennon L, Macfarlane PW, Murphy MB, Packard CJ, Stott DJ, Westendorp RG, Whincup PH, Shepherd J, Wannamethee SG

Waugh RE, Narla M, Jackson CW, Mueller TJ, Suzuki T, Dale GL