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The study contributed to a developing preclinical literature suggesting AOD-9604 may have applications in joint and cartilage research distinct from its original metabolic indication

When to increase dose Consider increasing if: Minimal response after 4-6 weeks at current dose No side effects at current dose Current dose below the higher end of recommended range Goals not being met with conservative approach Increase gradually, typically by 25-50% at a time

Reference: Monto RR

25 Volkov et al., who found that benefits were regardless of B12 status, discuss the possibility that patients in their study were deficient despite serum levels being within normal limits, as no other biomarker tests were carried out