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Tobacco smoking in the NDSHS

To address this gap, this study presents a larger case series of 17 patients who developed AEP as a result of smoking, with an aim of enhancing our knowledge of its triggers, clinical presentation, and outcomes

8.1.3 Metformin and other metabolic modulators Metformin, primarily known as an anti-diabetic medication, has been found to inhibit mitochondrial ATP and DNA synthesis, which can abrogate NLRP3 inflammasome activation and reduce pulmonary inflammation

This appears to have be taken out of the old anti-tobacco playbook, but without adjusting for risk-appropriateness and the concept of harm reductionperhaps because it requires coming to terms with the fact that mitigating harm is a lot more achievable and, therefore beneficial in practice, than being focused on completely eliminating use