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Nonetheless, when extracellular HSP70 is continuously elevated, it stimulates inflammation, oxidative stress, reduced expression of HSF-1, and possibly reduced intracellular HSP70 [91]

The slow intravenous infusion protocols used in clinical trials minimized these effects, suggesting that rapid bolus administration (which is essentially what subcutaneous injection creates) may increase the likelihood of transient side effects

When to consider a dose increase A genuine plateau means weight loss has stopped for at least 3-4 consecutive weeks despite consistent dosing, adherence to a moderate caloric deficit, and no changes in medication or health status that could explain the stall

Treatment generally takes take between 30-60 minutes per session