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In certain embodiments, any controlled release otic formulation or composition described herein increases the exposure of a therapeutic agent and increases the Area Under the Curve (AUC) in otic fluids (e.g., endolymph and/or perilymph) by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, or about 90% compared to a formulation or composition that is not a controlled release otic formulation or composition

[DOI] [PubMed] [Google Scholar] 55.Vecchiarelli H.A., Lopes L.T., Paolicelli R.C., Stevens B., Wake H., Tremblay M.

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Indeed, SARS-CoV-2 infection seems to cause -synuclein aggregation in the brains of COVID-19 cases [56]