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However, prolonged or high-dose ketamine exposure induces a compensatory upregulation of NMDARs, increasing intracellular calcium ion influx and ROS production, ultimately leading to neuronal apoptosis ( In animal studies, antagonism of NMDA receptors in intermediate neurons of the forebrain and thalamus reduces GABAergic function

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They do not impair judgment, coordination, or reaction time

The Science of Urine Color: Whats Normal and Whats Not The color of our urine is more than just a bodily function